IMAGING - Magnetic Resonance Imaging (MRI)
An objective demonstration of the presence and severity of inflammatory lesions is essential to optimizing and personalizing the management of inflammatory bowel diseases. Endoscopy has for many years been the gold standard for objectively assessing disease activity. In recent years, our group has shown that MRI can provide an accurate and reliable assessment of intestinal inflammatory lesions, and is superior to endoscopy in terms of assessing stricturing and penetrating complications. We have derived and validated a quantitative index of activity for Crohn’s disease, and shown that it is responsive to therapeutic interventions, thus making it a useful tool for clinical practice and for clinical trials.
Endoscopic Image: The sagittal volumetric interpolated breath hold examination (VIBE) shows the descending colon until the splenic angle. The VIBE 1 shows ulcers in the transvers colon until the hepatic angle. The image also shows a healthy ascending segment and a part of affected ileum.
We are further developing MRI-based applications to study inflammatory intestinal lesions to increase both the accuracy and tolerability of the examination for patients and radiologists, minimizing the preparation and time required. We are also developing new modalities to measure fibrosis in intestinal segments affected by Crohn’s disease, information that may have a considerable impact on patient management and that could facilitate the development of antifibrotic drugs.
- Instituto de Salud Carlos III; PI07/90253, PI: Jordi Rimola (Department of Radiology, Hospital Clínic Barcelona.
- Beca Geteccu Faes Farma; PI: Ingrid Ordás and Jordi Rimola.
Value of endoscopy and MRI for predicting intestinal surgery in patients with Crohn's disease in the era of biologics.
Jauregui-Amezaga A, Rimola J, Ordás I, Rodríguez S, Ramírez-Morros A, Gallego M, Masamunt MC, Llach J, González-Suárez B, Ricart E, Panés J.
Gut. 2015 Sep; 64(9): 1397-402.
doi: 10.1136/gutjnl-2014-308101. Epub 2014 Dec 16. / PMID: 25516418
Characterization of inflammation and fibrosis in Crohn's disease lesions by magnetic resonance imaging.
Rimola J, Planell N, Rodríguez S, Delgado S, Ordás I, Ramírez-Morros A, Ayuso C, Aceituno M, Ricart E, Jauregui-Amezaga A, Panés J, Cuatrecasas M.
Am J Gastroenterol. 2015 Mar; 110(3): 432-40.
doi: 10.1038/ajg.2014.424. Epub 2015 Jan 27.
Erratum in: Am J Gastroenterol. 2015 Mar;110(3):480. / PMID:25623654
Accuracy of magnetic resonance enterography in assessing response to therapy and mucosal healing in patients with Crohn's disease.
Ordás I, Rimola J, Rodríguez S, Paredes JM, Martínez-Pérez MJ, Blanc E, Arévalo JA, Aduna M, Andreu M, Radosevic A, Ramírez-Morros AM, Pinó S, Gallego M, Jauregui-Amezaga A, Ricart E, Panés J.
Gastroenterology. 2014 Feb; 146(2): 374-82.e1.
doi: 10.1053/j.gastro.2013.10.055. Epub 2013 Oct 29. / PMID: 24177375
Diagnostic accuracy of magnetic resonance colonography for the evaluation of disease activity and severity in ulcerative colitis: a prospective study.
Ordás I, Rimola J, García-Bosch O, Rodríguez S, Gallego M, Etchevers MJ, Pellisé M, Feu F, González-Suárez B, Ayuso C, Ricart E, Panés J.
Gut. 2013 Nov; 62(11): 1566-72.
doi: 10.1136/gutjnl-2012-303240. Epub 2012 Aug 30.