Transcriptional analysis of intestinal mucosa as a tool to understand

response or lack of response to therapy

Our lab has been intensely focused on the study of the transcriptional profiles of intestinal samples of both ulcerative colitis and Crohn’s disease patients. Whole genome transcriptional analysis has become an instrumental tool to understand and discover new pathological mechanisms as well as to define the molecular features of response or lack of response to different therapeutic strategies.



Evaluation of responsive-gene expression as a sensitive and specific biomarker in patients with ulcerative colitis.

Román J, Planell N, Lozano JJ, Aceituno A, Esteller M, Pontes C, Balsa D, Merlos M, Panés J, Salas A.


Inflamm Bowel Dis 19(2): 221-9;  2013

doi: 10.1002/ibd.23020. / PMID: 22605655


Identification of inflammatory mediators in Crohn’s disease patients unresponsive to anti-TNF-a therapy.

Leal RF, Planell N, Kajekar R, Lozano JJ, Ordás I, Dotti I, Esteller M, Masamunt MC, Parmar H, Ricart E, Panés J, Salas A.


Gut 64(2):233-42; 2014

doi:10.1136/gutjnl-2013-306518 / PMID: 24700437